Dating for drugs

29-Apr-2017 11:55

Solutions are in contact with the polyethylene layer of this container and can leach out certain chemical components of the plastic in very small amounts within the expiration dating period.

The suitability of the plastic has been confirmed in tests in animals according to the USP biological tests for plastic containers, as well as by tissue culture toxicity studies.

plastic container (PL 2040) contains ceftizoxime as ceftizoxime sodium.

It is a sterile, semisynthetic, broad spectrum, cephalosporin antibiotic for intravenous administration.

Chemically, it is the sodium (6 plastic container is a frozen iso-osmotic, sterile, nonpyrogenic premixed 50 m L solution containing 1 g or 2 g of ceftizoxime as ceftizoxime sodium.

Dextrose, USP has been added to these dosages to adjust osmolality (approximately 1.9 g and 950 mg to the 1 g and 2 g dosages as dextrose hydrous, respectively).

This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used.

This category also provides a buffer zone, which prevents small-uncontrolled technical factors from causing major discrepancies in interpretation.

The MIC values should be interpreted according to the following criteria: The current absence of data on resistant strains precludes defining any category other than “susceptible”.This procedure uses paper disks impregnated with 30-μg ceftizoxime to test the susceptibility of microorganisms to ceftizoxime.Reports from the laboratory providing results of the standard single-disk susceptibility test with a 30-μg ceftizoxime disk should be interpreted according to the following criteria: The current absence of data on resistant strains precludes defining any category other than “susceptible”.Ceftizoxime is highly resistant to a broad spectrum of beta­lactamases (penicillinase and cephalosporinase), including Richmond types I, II, III, TEM, and IV, produced by both aerobic and anaerobic gram­positive and gram­negative organisms.Ceftizoxime has been shown to be active against most strains of the following microorganisms, both minimum inhibitory concentration (MIC) less than or equal to the susceptible breakpoint for ceftizoxime.

The MIC values should be interpreted according to the following criteria: The current absence of data on resistant strains precludes defining any category other than “susceptible”.

This procedure uses paper disks impregnated with 30-μg ceftizoxime to test the susceptibility of microorganisms to ceftizoxime.

Reports from the laboratory providing results of the standard single-disk susceptibility test with a 30-μg ceftizoxime disk should be interpreted according to the following criteria: The current absence of data on resistant strains precludes defining any category other than “susceptible”.

Ceftizoxime is highly resistant to a broad spectrum of beta­lactamases (penicillinase and cephalosporinase), including Richmond types I, II, III, TEM, and IV, produced by both aerobic and anaerobic gram­positive and gram­negative organisms.

Ceftizoxime has been shown to be active against most strains of the following microorganisms, both minimum inhibitory concentration (MIC) less than or equal to the susceptible breakpoint for ceftizoxime.

These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds.